Significance of pretransplant and de novo anti-HLA antibody detection after simultaneous pancreas-kidney transplantation

Introduction. Nowadays, there are few studies concerning assessment of the clinical significance determining level pretransplant and de novo anti-HLA antibodies in patients after simultaneous pancreas-kidney transplantation. Aim. The study incidence, timing formation specificity Material methods. We conducted a prospective retrospective research to 55 transplantation performed at N.V. Sklifosovsky Research Institute for Emergency Medicine from 2008 2022. Results. There were 4 with preformed (7%). was observed 17 (31%). 5 antiHLA class I, 3 II, I anti-MICA 1 patient both classes anti-MICA. significantly increased incidence acute rejection (47% compared 13%, p=0.014). Conclusion. frequency antibody detection recipients our Center is comparable published data other transplant centers. obtained evidence that increases